Researchers describe molecular signalling regulated by mTOR among memory and exhausted cytotoxic CD8+ T lymphocytes.
By Pooja Toshniwal PahariaAug 18 2023Reviewed by Benedette Cuffari, M.Sc. Cytotoxic T lymphocytes play a crucial role in adaptive immunity, primarily defending against tumors and viruses. These cells develop within the thymus gland and undergo rapid activation upon encountering an antigen.
Study: Regulation of CD8+ T memory and exhaustion by the mTOR signals. Image Credit: fusebulb / Shutterstock.com T-cell receptor stimulation is the major cause of T lymphocyte exhaustion, with exhausted cells constituting a unique cytotoxic subset. Tex cells produce lower levels of cytokines and fewer cytotoxic effector molecules.
Effector cells primarily undergo aerobic glycolysis, while memory cytotoxic T-cells exhibit enhance OXPHOS and fatty acid oxidation. Chronic infection or tumorigenesis impairs major metabolic pathways, thereby making Tex cells highly dependent on glycolysis. MPECs differentiate to form central memory T , residential memory T , and effector memory T lymphocytes. The Sin1/mTORC2 complex may directly regulate the GATOR1-KICSTOR complex, controlling cell growth, metabolism, immune responses, and tumorigenesis.
Danmark Seneste Nyt, Danmark Overskrifter
Similar News:Du kan også læse nyheder, der ligner denne, som vi har indsamlet fra andre nyhedskilder.
Researchers find heartbeat relies on surprisingly large network of proteinsThe first mapping of the heart's crucial ion channels reveals a surprisingly extensive network of proteins. This understanding is the first step towards more precise treatment for patients with cardiac arrhythmias.
Læs mere »
Researchers discover contrast dye shortage affected assessment of stroke patientsUniversity of Missouri School of Medicine neurologist Adnan Qureshi, MD recently led a study that discovered last year's iodinated media contrast dye shortage affected the assessment of stroke patients at hospitals across the country. Injecting or drinking the media contrast helps doctors see blood vessels and organs more clearly in an X-ray or a computed tomography (CT) scan.
Læs mere »
Researchers develop new rapid and reliable method for SARS-CoV-2 detectionCommercially available mass spectrometers can reliably detect the SARS-CoV-2 coronavirus. In the journal 'Clinical proteomics' researchers from the Martin Luther University Halle-Wittenberg (MLU) present a new method which employs equipment that is already being used in hospitals and laboratories to detect bacterial and fungal infections.
Læs mere »
Cyber security researchers become target of criminal hackers\n\t\t\tKeep abreast of significant corporate, financial and political developments around the world.\n\t\t\tStay informed and spot emerging risks and opportunities with independent global reporting, expert\n\t\t\tcommentary and analysis you can trust.\n\t\t
Læs mere »
Researchers say Microsoft won't fix PowerShell Gallery flawsBillions of downloads and no defense against typosquatting feels like a bad combination in this day and age
Læs mere »
Researchers combine deep learning and physics to fix motion-corrupted MRI scansCompared to other imaging modalities like X-rays or CT scans, MRI scans provide high-quality soft tissue contrast. Unfortunately, MRI is highly sensitive to motion, with even the smallest of movements resulting in image artifacts. These artifacts put patients at risk of misdiagnoses or inappropriate treatment when critical details are obscured from the physician. But researchers at MIT may have developed a deep learning model capable of motion correction in brain MRI.
Læs mere »