A study in Environmental Health assesses the effects of chlordecone (an insecticide) exposure in children from Guadeloupe. It provides new insights on its potential neurotoxicity that persists in the French West Indies population decades after its ban.
Blood samples from the umbilical cord and the child at the 7-year visit were collected in EDTA tubes to document respectively prenatal and childhood exposure to chlordecone and other environmental contaminants. Plasma samples were stored at -30 °C in Polypropylene Nunc® tubes following centrifugation. Chlordecone, polychlorinated biphenyl congener 153 , dichlorodiphenyl dichloroethene and lipids were measured in plasma.
], maternal alcohol consumption and smoking during pregnancy . We included in multivariable models, child’s age and sex, maternal age, parity, Raven score, education, marital status, monthly household income, and alcohol and smoking during pregnancy.Chlordecone and other chemicals’ concentrations were log-transformed to address skewness and limit the influence of outliers. Values below limit of detection were replaced by LOD/].
First, we used structural equations modeling adjusting for the same set of covariates to investigate simultaneously the associations between cord- and 7-years exposures, with WISC-IV and SDQ scores. We ran two separate analyses for the cognitive and behavioral functions. For the WISC-IV scores, we employed a simple path analysis to incorporate all outcomes in a single model.
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