Researchers performed an open-label phase I trial.
By Neha MathurAug 18 2023Reviewed by Lily Ramsey, LLM In a recent article published in Nature Medicine, researchers performed an open-label phase I trial wherein they applied deep brain stimulation to the cerebellar dentate nucleus to promote functional reorganization of the ipsilesional cortex.
Despite substantial effort and investment, technological leaps for the post-acute phase of stroke have been slower. About the study In the present study, researchers proposed another novel, invasive surgical approach to extend the temporal window and the extent of neuroplasticity in 12 patients with moderate to severe upper-extremity impairment after stroke.
The study participation spanned 20 to 24 months, with monthly assessments performed to record safety data and secondary metrics. Following enrollment, participants underwent one month of upper-extremity rehabilitation to rule out the potential for recovery with rehabilitation therapy.
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