New research has identified which people with compromised immune systems are less likely to have COVID-19 antibodies - making them more vulnerable to a severe infection.
Around one in five people with solid organ transplant, rare autoimmune disease or blood cancer affecting lymphocytes had no COVID-19 antibodies after three or more vaccinations.
The findings published in The Lancet Rheumatology will help to better plan care and treatment for people living with these conditions. People who are less likely to have COVID-19 antibodies could be offered antibody testing and targeted interventions, such as further vaccine doses or preventative medicine. The absence of antibodies could also influence which immunotherapy medications are given to those with different underlying conditions.
People with suppressed immune systems could choose to enroll in the study if they had received at least three COVID-19 vaccine doses. More than 23,000 people took part by doing a home finger-prick antibody test and reporting the results using an online portal.
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