Pediatric acute myeloid leukemia genetic subtypes with poor outcomes show increased inflammatory cytokine signaling natureportfolio BRIseattle AML AcuteMyeloidLeukemia Genetics Subtype PediatricAML
By Dr. Chinta SidharthanNov 29 2022Reviewed by Aimee Molineux In a recent study published in Nature Communications, researchers used ribonucleic acid sequence data to understand the association between inflammatory cytokines and poor outcomes of pediatric Acute Myeloid Leukemia .
Treatment with JAK/STAT pathway inhibitors or antibodies that neutralize IL-6 has shown promise in adult AML cases. Understanding the role of IL-6 signaling in pAML and the association of IL-6 with the pAML subtypes with poor clinical outcomes can further the development of broad targeted therapies for various subtypes.
Bone marrow cells from pAML patients expressing high levels of IL-6 and IL-6 receptors were cultured in human bone marrow stromal cells , which replicate the patterns of bone marrow stromal cell expression such as secretion of IL-6, IL-1β, the ligand for receptor-type protein-tyrosine kinase , and macrophage/granulocyte colony-stimulating factors M-CSF, G-CSF, and GM-CSF.
Results The results reported that more than 20% of pAML patients had high levels of IL-6 and higher inflammatory cytokine signaling activity, such as TNF-α, IFNα and IFNβ, and IL-1. These high levels of inflammatory cytokines and signaling activity were also associated with poor outcomes, such as a lower probability of event-free and overall survival for two years.
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