The study reveals that oral semaglutide, a medication primarily used for type 2 diabetes, effectively reduces body weight and blood glucose levels in diet-induced obese mice. The findings suggest that this drug could be a promising treatment for obesity and offer a suitable animal model for future research.
By Neha MathurSep 3 2023Reviewed by Benedette Cuffari, M.Sc. In a recent study published in the journal Nutrients, researchers investigate the metabolic effects of oral semaglutide in diet-induced obese mice.
The PIONEER 1 study showed that seven and 14 mg oral semaglutide significantly reduced hemoglobin A1C and body weight at 26 and 52 weeks of treatment, respectively, in T2D patients. Moreover, 14 mg oral semaglutide reduced body fat mass and energy intake of T2D patients within 12 weeks and increased satiety in people eating high-calorie breakfasts. Oral semaglutide was also found to be more effective in reducing body weight than dulaglutide and liraglutide, both of which are also GLP-1RAs.
Four-week-old male DIO mice weighing between 50-55 g were separated into three groups with seven mice each. The first and second groups received oral semaglutide 0.23 mg/kg, which was equivalent to a 14 mg human dose in 0.5 or 0.1 mL distilled water , respectively. Controls received 0.23 mg/kg semaglutide with 0.5 mL DW.
DIO mice aged 36 weeks were also divided into three groups based on their BW and FI. The two test group animals received oral semaglutide at 0.23 and 0.7 mg/kg dosages in 0.1 mL DW, whereas controls received 0.5 mL DW. Additional mice also received oral semaglutide once daily for three days, during which their daily FI and BW were measured at 16:00. FI was also measured in the light phase between 8:00 and 16:00 before fasting, as well as between 20:00 and 8:00 the next day, which was defined as the dark phase .
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