Apolipoprotein plays a critical role in modulating microglial responses and related lipid metabolism upon neuronal injury, which may cause neurodegenerative diseases, reports a study published in MolNeuro
], allowing us to examine the impacts of apoE isoforms on microglial behavior upon demyelination. We first assessed the effect of CPZ treatment on brain myelin integrity in control and CPZ-treated mice by immunohistochemical staining using an antibody specific to intact myelin basic protein .
ApoE-TR mice were fed with either normal diet , or cuprizone-containing diet for 4 weeks.Myelin integrity in the corpus callosum of experimental mice was evaluated by immunostaining using an antibody specific to intact myelin basic protein . Representative images of the CC region are shown. Scale bar, 100 µm.Myelin accumulation in the form of myelin debris was examined by immunostaining using an antibody specific to degraded myelin basic protein .
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