Novel arterivirus discovered in Amazonian rodents unveiling a potential viral spillover threat Arteriviridae arterivirus RNAseq RNA virus Sigmodontinae Amazon VirusesMDPI
By Dr. Priyom Bose, Ph.D.May 14 2023 The increase in high throughput sequencing technologies has broadened the known diversity of the virosphere. These technologies have enhanced the frequency and accuracy of viral surveillance. In an Amazonian metropolitan region, scientists have been studying the viral communities associated with the human-animal interface. Now, a recent study in the journal Viruses focused on the identification of a novel rodent-borne arterivirus.
Viruses belonging to the Arteriviridae family have been characterized as spherical, enveloped, single-stranded, and positive-sense multi-cistron RNA genomes. In the context of their genomic organization, a marginal variation in the open reading frame was observed among all species belonging to the Arteriviridae family. Conserved domains have been identified that include ORFs 1a and 1b .
About the Study The current study is part of a large surveillance study to explore the viral communities associated with wild mammals at the human–animal interface. Tissue samples were collected from wild mammals in Santa Bárbara do Pará, Brazil. For this study, animals were captured using Tomahawk and Sherman traps in forest areas with close human habitations and agricultural practices. A total of 39 mammals, 12 rodents, 18 marsupials, and 9 chiropterans were captured.
Study Findings An almost complete genome was retrieved, which contained four final contigs related to known arterivirids. The genomic sequence revealed that the virus was a member of the Arteriviridae family.
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