The blood-brain barrier, the body's way of shielding sensitive brain tissue from viruses, toxins and other harmful substances in the blood, can pose a problem for physicians caring for patients with suspected brain diseases such as cancer.
that close within a few hours, leaving no lasting damage. That window of time is long enough for biomolecules from the lesion to escape into the blood, where they can be collected with an ordinary blood draw.
"With this capability to noninvasively, nondestructively access every part of the brain, we can get genetic information on tumors before going in surgically, which would help a neurosurgeon determine how best to approach the surgery. If they see something suspicious on imaging, they could confirm whether ais recurring or not. We can now start to interrogate diseases for which surgical biopsies aren't done, such as neurodevelopmental, neurodegenerative and psychiatric disorders.
"It's very easy to use," Leuthardt said."We used it in the OR for this study, but it could be used in a clinic or at a patient's hospital bedside. It's a step toward democratizing access to advanced diagnostics. We can interrogate patients' brains, and we don't need a high-tech, multimillion-dollar scanner to do it."
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