A Japanese research team led by the National Cerebral and Cardiovascular Center Research Institute has identified for the first time progenitor cells that specifically transform into the contractile cells of the left ventricle during heart development. Identifying one of the diverse progenitor cells involved in the formation of the heart will guide future studies and enable a better understanding of congenital heart diseases.
is a four-chamber organ containing various types of cells, each of which undergoes a different journey during embryologic development to reach its final form. Researchers in Japan have now advanced our understanding of this multifaceted process, which can shed light on the mechanisms underlyingTo appreciate their research achievement, we first need to know a little about the development of the heart. Cardiomyocytes are the major contractile cells of the heart.
Frontal Z-stack images of a Hey2 enhancer-LacZ embryo stained for LacZ, Nkx2-5, and Hand1 at the early CC phase. Credit:In an article published in the, a Japanese research team led by the National Cerebral and Cardiovascular Center Research Institute addressed this question.progenitor In the early phase, these newly identified Hey2 enhancer-active cells are located right next to the already known common progenitor cells; they then overlap with each other, suggesting that the progenitor cells for left ventricular cardiomyocytes are initially heterogenous.
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