Newly engaged Nicole Scherzinger and Thom Evans flaunt gym-honed figures on sunny holiday
Love-up Nicole Scherzinger looked spectacular as she showed off her incredible, bronzed figure while enjoying the sunshine on a trip to Greece with her new fiancé Thom Evans.
Last week, the former X Factor judge delighted her fans when she announced her engagement to former Scottish rugby union player Thom. Made In Chelsea's Ollie Locke also shared his joy for the pair, commenting on Thom's post with, "Ohh guys. I'm soooo happy for you both!! Such wonderful news Xxxxxx", while Love Island's Wes Nelson penned three simple red hearts.
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Human papillomavirus integration transforms chromatin to drive oncogenesis - Genome BiologyBackground Human papillomavirus (HPV) drives almost all cervical cancers and up to 70% of head and neck cancers. Frequent integration into the host genome occurs predominantly in tumorigenic types of HPV. We hypothesize that changes in chromatin state at the location of integration can result in changes in gene expression that contribute to the tumorigenicity of HPV. Results We find that viral integration events often occur along with changes in chromatin state and expression of genes near the integration site. We investigate whether introduction of new transcription factor binding sites due to HPV integration could invoke these changes. Some regions within the HPV genome, particularly the position of a conserved CTCF binding site, show enriched chromatin accessibility signal. ChIP-seq reveals that the conserved CTCF binding site within the HPV genome binds CTCF in 4 HPV+ cancer cell lines. Significant changes in CTCF binding pattern and increases in chromatin accessibility occur exclusively within 100 kbp of HPV integration sites. The chromatin changes co-occur with out-sized changes in transcription and alternative splicing of local genes. Analysis of The Cancer Genome Atlas (TCGA) HPV+ tumors indicates that HPV integration upregulates genes which have significantly higher essentiality scores compared to randomly selected upregulated genes from the same tumors. Conclusions Our results suggest that introduction of a new CTCF binding site due to HPV integration reorganizes chromatin state and upregulates genes essential for tumor viability in some HPV+ tumors. These findings emphasize a newly recognized role of HPV integration in oncogenesis.
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