New technologies and recent advances in the study of T cells and T-cell epitope discovery in food allergy research jacionline ljiresearch Tcell foodallergy allergy allergies immunity immunology
By Dr. Priyom Bose, Ph.D.Nov 28 2022Reviewed by Danielle Ellis, B.Sc. Although food allergies have been prevalent for many years, their incidence has recently increased. This review is available in the Journal of Allergy and Clinical Immunology.
The US Food and Drug Administration recently approved oral immunotherapy for peanut allergy; however, this treatment is only effective for patients with mild allergic reactions. Improved characterization of the phenotypic markers of allergen-specific T-cells would augment the opportunities to develop effective diagnostics and treatment for food allergies.
Although only a few food allergen epitopes have been discovered at present, it is a fast-growing field of research. The discovery of more T-cell epitopes for different food allergens will help better characterize antigen-specific T-cell profiles. Comparison of different antigen-specific T-cell profiles of specific antigens and correlating them with an individual’s allergic disease status will shed light on the similarities and dissimilarities in the T-cell phenotypes in food allergies.
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