New research supported by the Medicines and Healthcare products Regulatory Agency (MHRA) has shown that the time to detect polio can be halved using a technique called Direct molecular Detection and Nanopore Sequencing (DDNS), supporting the global effort to eradicate polio and help save lives.
A new study, ‘Sensitive poliovirus detection using nested PCR and nanopore sequencing: a prospective validation study’, published yesterday in Nature Microbiology, proves that using DDNS to detect polio outbreaks can save public health authorities crucial time and money.
By enabling samples to be tested in the country where the outbreak originated rather than being sent to specialist laboratories abroad, the costs and delays of transport and testing can be reduced from an average of 42 days to an average of 19 days. Researchers also tested this technique in the UK and detected poliovirus in London in 2022, leading to the recent drive to ensure children under the age of 12 are vaccinated through the London polio catch-up campaign 2023.
“The support and guidance of the Bill and Melinda Gates Foundation and the GPLN, who make these collaborations possible, enables the application and expansion of DDNS across Africa for the rapid detection of poliovirus and outbreak response, helping us move closer towards polio eradication.” “The sequencing technology used in this method is easily adapted for the detection and typing of other organisms. This rollout will therefore provide a foundation of skills and experience that can be redirected to the genomic surveillance of other pathogens as needed.”
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