As we age, our bodies face numerous challenges, including a decline in immune system function and an increased vulnerability to various health issues. An innovative study has recently shed light on these challenges and unveiled a potential solution that could have far-reaching implications for aging individuals.
, led by Nicola Vannini, group leader in the Department of oncology UNIL-CHUV in Lausanne and member of the Lausanne branch of the Ludwig Institute for Cancer Research, focused on a key player in the blood system—These cells are responsible for generating various types of blood cells, playing a critical role in maintaining a healthy immune system.
Urolithins are not found in food; however, their precursors are. Urolithin A is the result of transformation of ellagic acids and ellagitannins by the gut microflora in humans. Ellagitannins are found in pomegranates, nuts, some berries.
in aged mice. When Urolithin A was incorporated as a dietary supplement, it not only revitalized the immune system's lymphoid compartments but also enhanced overall HSC performance., showcasing the potential of Urolithin A to combat age-related immune system decline. In essence, this research indicates that by encouraging the recycling of mitochondria using Urolithin A, it is possible to reverse the aging process within the hematopoietic and immune systems. These findings hold immense promise for the development of interventions targeted at addressing age-related health conditions in older individuals and pave the way for envisioning clinical trials.
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