New single-dose treatment for sleeping sickness could help eliminate transmission of the disease by 2030 thelancet TheLancetInfDis
A new, single-dose, oral treatment for sleeping sickness is as effective as current treatments and could be a key factor in eliminating disease transmission by 2030, suggests a new study published inSleeping sickness, or human African trypanosomiasis , is a neglected tropical disease, which can be fatal if left untreated. The Gambiense human African trypanosomiasis form of the disease is found across countries in west and central Africa with most cases in the Democratic Republic of Congo.
The new prospective study looks at the efficacy of one oral dose of acoziborole, a drug co-developed by DNDi and Sanofi, in treating g-HAT. During the study, which recruited patients from 10 hospitals in the Democratic Republic of Congo and Guinea, a single 960 mg oral dose of acoziborole was administered to 208 patients; 167 diagnosed with late-stage HAT and 41 with early/ intermediate-stage g-HAT. The patients were followed up for 18 months to see if treatment was successful.
The proportion of side effects related to treatment was low and all events were mild or moderate. No significant drug-related safety signals were identified in this study.
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