Two multi-polygenic scores (muti-PGs) to predict coronary heart disease (CHD).
By Pooja Toshniwal PahariaSep 28 2023Reviewed by Lily Ramsey, LLM In a recent study published in the European Journal of Human Genetics, researchers developed two multi-polygenic scores to predict coronary heart disease by weighing and linearly integrating phenotypic genome sequences for CHD and numerous other features.
About the study The present study investigated whether a polygenic score with various PGS for different CHD-related features would be more strongly linked with coronary heart disease than a coronary heart disease-specific phenotypic genome sequence. The Human Reference Consortium panel imputed ARC genotype data. Regeneron Genetics genotyped 1.4 million variations in the community-dwelling Mayo Biobank population utilizing the Twist Diversity single-nucleotide polymorphism panel.
Results In models including 10 PCs, age, and gender, a one-standard-deviation elevation in extendedPGSCHD and multiPGSCHD was linked to a 1.7-fold and 1.7-fold increased chance of coronary heart disease, respectively, among Mayo Biobank individuals. The Mayo Biobank also employed PGSCHD and multiPGSCHD for persons of non-European heritage. When tested on the same training set, the lasso model had an area under the curve of 0.8.
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