New insights into severe obesity genetics: Evidence from adults seeking treatment reveals intriguing oligogenic patterns medrxivpreprint imperialcollege Bruneluni genetcis obesity health disease
By Dr. Priyom Bose, Ph.D.Aug 14 2023Reviewed by Benedette Cuffari, M.Sc. Obesity is a complex disorder that is dependent on environmental and genetic factors. Severe obesity, which is otherwise known as class III obesity, is a chronic condition that increases the risk of mortality and morbidity.
*Important notice: medRxiv publishes preliminary scientific reports that are not peer-reviewed and, therefore, should not be regarded as conclusive, guide clinical practice/health-related behavior, or treated as established information. Although the effect of oligogenic inheritance has been established for many diseases, there is a lack of evidence regarding its influence on severe obesity.
The newly developed genotyping array was applied to 1,714 unrelated adults seeking treatment for severe obesity. These participants were recruited between 2011 and 2021 for the Personalised Medicine for Morbid Obesity National Health Service -registered portfolio trial. The results of the genetic screen were compared with the clinical cohort containing 50,000 whole exome sequencing datasets from the U.K. Biobank.
As compared to previous studies, the current study observed a higher prevalence of possible Mendelian obesity. This disparity in results could be due to other studies considering variants from fewer genes. The findings of the custom-designed rare-variant genotyping array were compared with the WES dataset of the UKB cohort, which revealed that the overall prevalence of qualifying variants was not significantly different. This finding was surprising, as the UKB cohort represented healthy individuals.
Danmark Seneste Nyt, Danmark Overskrifter
Similar News:Du kan også læse nyheder, der ligner denne, som vi har indsamlet fra andre nyhedskilder.
What is the prevalence of current alcohol consumption and of risky alcohol consumption among cancer survivors in the US?What is the prevalence of current alcohol consumption and of risky alcohol consumption among cancer survivors in the US? JAMANetworkOpen alcohol consumption alcoholconsumption cancer canceresearch cancersurvivors risky riskyalcoholconsumption
Læs mere »
Letters to The Mag - Newcastle United fans having their say ahead of new season kicking offNewcastle United fans having their say ahead of new season kicking off - Letters to The Mag.
Læs mere »
Researchers design one-step procedure for improving effective of adoptive cell immunotherapy against solid tumorsResearchers design one-step procedure for improving effective of adoptive cell immunotherapy against solid tumors ScienceAdvances cellimmunotherapy immunotherapy tumors adoptive
Læs mere »
University marking boycott: Robert Halfon calls for talks to end disputeRobert Halfon calls for new talks to stop the boycott continuing into the new academic year.
Læs mere »
The photo all Newcastle United fans were REALLY so desperate to seeI am loving it, just loving it...The photo all Newcastle United fans were so desperate to see.
Læs mere »
Unai Emery reacts to getting schooled by Eddie Howe - Aston Villa hammered by Newcastle UnitedAston Villa hammered by Newcastle United - Unai Emery reacts to getting schooled by Eddie Howe
Læs mere »