itemprop=description content=A UCLA-led team of researchers has found nerve pathways that supply brown adipose tissue (BAT), a type of tissue that releases chemical energy from fat metabolism as heat – a finding that could pave the way toward using it to treat obesity and related metabolic conditions.
Reviewed by Megan Craig, M.Sc.Oct 5 2023 A UCLA-led team of researchers has found nerve pathways that supply brown adipose tissue , a type of tissue that releases chemical energy from fat metabolism as heat – a finding that could pave the way toward using it to treat obesity and related metabolic conditions.
We know from previous literature that the sympathetic nerve system is the main 'on switch' for BAT activity. However, the sympathetic nervous system is also responsible for many other stimulatory effects on organs such as the heart and gut. Finding a way to increase activity of BAT alone has been challenging, so finding out the path these sympathetic nerves take to BAT will allow us to explore ways of using nerves to provide a very specific stimulus to activate BAT.
"There is a need to find long-term solutions for obesity, and while we are lucky to have effective drugs such as Wegovy and Mounjaro, people need to take them long term for weight loss," Srikanthan said. "There is literature suggesting -- and we are doing another study to confirm it -- that these drugs act by stimulating BAT," she said. "By identifying the nerve pathways supplying BAT we hope to explore methods of chronically stimulating nerves to BAT and hopefully achieving similar therapeutic outcomes of weight loss."
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