New brain-penetrant agonist shows promise in protecting dopamine neurons for Parkinson's disease treatment NatureComms harvardmed parkinsons Nurr1 therepeutic target PD dopamine
By Pooja Toshniwal PahariaJul 20 2023Reviewed by Lily Ramsey, LLM In a recent study published in Nature Communications, researchers reported on Nurr1 as a promising therapeutic target for managing Parkinson's disease .
About the study In the present study, researchers investigated whether genetic [such as alpha-synuclein ] and environmental [such as mitochondrial complex I inhibitor, 1-methyl-4-phyenylpyridinium positivity] risk factors for Parkinson's disease affect Nurr1 expression and function. For Nurr1 stability determination, MN9D cells were incubated with MPP+ or transduced with lentivirus expressing green fluorescent protein only or αSyn.
Adeno-associated viruses -αSyn-induced PD mice were subjected to various tests, assessing motor , as well as non-motor behaviors . Pathogenic αSyn overexpression led to a larger decrease in Nurr1 levels compared to the wild-type. The findings indicated that compromised Nurr1 expression and function might underlie mDAN degeneration in sporadic and familial Parkinson's disease, contributing to disease pathogenesis. Nurr1 ligands could regulate Nurr1 levels at the post-transcriptional level.
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