Nanoparticle-Based Antimicrobial Fabrics Tested Against SARS-CoV-2: nanoparticles SARSCoV2
By Bhavna KavetiAug 9 2022Reviewed by Susha Cheriyedath, M.Sc. Coronavirus disease 2019 , caused by severe acute respiratory syndrome coronavirus type 2 has severely affected the global economy and health systems. Consequently, there have been concerns about manufacturing personal protective equipment based on antimicrobial fibers to prevent the transmission of hazardous pathogens.
The results revealed that the prepared fabrics based on antimicrobial nanoparticles were active against the bacteria. However, these fabrics could reduce only a part of SARS-CoV-2 for a short time. Here, only viral surface particles were damaged, while the RNA of SARS-CoV-2 remained intact. ZnO and Ag can inhibit the growth of a wide range of microorganisms and are used in academic and industrial research. Hence, owing to their intrinsic antimicrobial property, they can destroy various bacteria and viruses due to the generation of reactive oxygen species induced by the metal ion release.
ZnO, Ag, and Ag/ZnO Antimicrobial Nanoparticles Against SARS-CoV-2 In the present work, silver , zinc oxide , and Ag/ZnO nanoparticles were fabricated via sonochemistry and fixed on the surface of the cotton fabric. The research finding revealed that these nanoparticles did not show effective antimicrobial activity against SARS-CoV-2 when integrated into cotton fibers.
Additionally, ROS disrupted the bacterial cell membrane by inducing oxidative stress, destroying the biomolecules involved in the make-up of the cell membrane. Furthermore, Ag/ZnO-based antimicrobial nanoparticles showed a higher inhibition zone against E. coli than ZnO or Ag-based individual counterparts.
Moreover, the data obtained from molecular biology suggested that prepared antimicrobial nanoparticles disrupted the structural components on the surface of infectious SARS-CoV-2 particles. However, the viral RNA remained unaffected, indicating inefficient antimicrobial activity against SARS-CoV-2.
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