Mpox has been silently circulating in non-mpox-endemic nations for 20 years, according to new study CDCgov Mpox MpoxVirus Transmission VirusCirculation
By Bhavana KunkalikarJan 19 2023Reviewed by Aimee Molineux In a recent study published in Emerging Infectious Diseases, researchers described the evolution of the mpox virus before the 2022 outbreak.
Portugal announced the first MPXV genome sequence from the epidemic on 19 May 2022, and many more sequences that give information on viral transmission are available. Early phylogenetic analysis suggested that the virus responsible for the 2022 MPXV outbreak was from the MPXV clade II, which is found to have less severity than clade I. This suggested that the recent MPXV introduction into communities from non-MPXV-endemic nations led to the outbreak.
Like the most recent common ancestor for the 2017–2018 epidemic, the MRCA for the outbreak in 2022 may be traced back almost 20 years. In addition, the 2022 outbreak MPXVs were more closely linked to strains exported from Africa at the time of the last outbreak than to strains prevalent in Nigeria around that time. Additionally, a strain from an individual traveling to the US from Nigeria in 2021 could also be associated with the source of the outbreak in 2022.
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