Molecular insights: Detecting gene fusions offers new avenues for advanced cancer management BiologicsMDPI genefusions cancermanagemnt cancer gene genetics cancertreatment
By Neha MathurAug 8 2023Reviewed by Lily Ramsey, LLM In a recent article published in the Biologics Journal, researchers examined de-identified clinical data to identify gene fusions by next-generation deoxy- and ribonucleic acids sequencing to understand their relationship with observed pathologies in a diverse population of cancer patients.
About the study In the present study, researchers analyzed formalin-fixed paraffin-embedded 4,415 samples derived from solid tumors of diverse cancer patients through two commercial labs in the USA between 2016 and 2022. A pathologist closely reviewed FFPE specimens to confirm the tumor size, content, and quality.
Related StoriesFurthermore, the researchers used OncoKB, a precision oncology knowledge base, to classify identified gene fusions into two groups, unclassified and known oncogenic gene fusions. Of all the new oncogenic gene fusions identified in this study, bone morphogenetic protein receptor 1B -PDZ and LIM Domain 5 and in-frame nipped-B-like protein -piezo type mechanosensitive ion channel component 1 fusions are described in detail below.
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