Targeted cancer drugs are widely used because of their ability to inhibit specific proteins involved in cancer development with fewer side effects compared to chemotherapy drugs.
Reviewed by Danielle Ellis, B.Sc.Oct 16 2023 But targeted therapies can often inhibit other unknown proteins. These hidden targets may also contribute to the drug's anticancer effects and potentially offer a path for the drug to be repurposed for other cancers controlled by the hidden target.
Drugs with polypharmacology mechanisms, meaning agents that target multiple functionally relevant proteins, may have the potential to effectively overcome drug resistance, improve anti-cancer activity of single-targeted inhibitors and produce a more durable patient response and remission." Rix and a team of Moffitt researchers wanted to determine whether cancer drugs that target the protein ROS1 in non-small cell lung cancer have additional hidden targets.
Related StoriesThe team performed additional laboratory experiments and found that lorlatinib also targets the protein PYK2. This protein plays an important role in focal adhesions, which are cell structures that are involved in several processes including cell adhesion, movement and survival. Their studies also showed that the protein SRC physically associated with PYK2 and ROS1 and helped control the activity of PYK2.
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