Medik8’s anti-ageing Vitamin C Serum has shoppers raving about its results, saying they’d noticed their skin was brighter and firmer after just one week of using it
The battle against signs of ageing has long been at the forefront of many people's skincare routines, with hundreds of products out there promising to reduce the appearance of fine lines and wrinkles.
The product’s vitamin C and E ingredients help protect your skin from the damage caused by free radicals such as sun exposure, which can cause your skin to age prematurely, whilst the Tetrahexyldecyl ascorbate content is a stabilised form of vitamin C which helps stop it from being too harsh on sensitive skin.
Another happy customer wrote: “I was pleasantly surprised by how this serum moisturises and tightens the skin. Every day it refreshes my skin and makes it consistent and well-groomed.”
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Identification of indications for albumin administration in septic patients with liver cirrhosisBackground Albumin infusion is the primary therapeutic strategy for septic patients with liver cirrhosis. Although recent studies have investigated the efficacy of albumin in the resuscitation stage of septic patients with liver cirrhosis, it remains unclear whether daily albumin administration can improve outcomes. Furthermore, the indications for initiating albumin therapy are not well defined. Methods Septic patients with liver cirrhosis were obtained from the Medical Information Mart for Intensive Care (MIMIC-IV 2.0) database. Marginal structural Cox models were employed to investigate the association between daily albumin infusion and 28-day mortality. We also aimed to explore under what circumstances enrolled patients could benefit most from albumin administration, based on the clinical parameters collected on the day of albumin infusion, including serum albumin concentration, serum lactate concentration, mean arterial pressure (MAP), and vasopressor dosage. Results A total of 2265 patients were included in the final analysis, of whom 1093 (48.3%) had received albumin treatment at least once. The overall 28-day mortality was 29.6%. After marginal structural modeling, daily albumin infusion was associated with a reduced risk of 28-day death (hazard ratio, 0.76; 95% CI 0.61–0.94). We found that patients benefit most from albumin infusion when initiated on the day of serum albumin concentration between 2.5 and 3.0 g/dL, serum lactate concentration greater than or equal to 2 mmol/L, MAP less than 60 mmHg, or vasopressor dosage between 0.2 and 0.3 mcg/kg/min (norepinephrine equivalent, NEE). Conclusions Albumin infusion is associated with a reduction in mortality in septic patients with liver cirrhosis under specific circumstances. Serum albumin concentration, serum lactate, MAP, and vasopressor dosage were found to be modifiers of treatment effectiveness and should be considered when deciding to initial albumin infusion.
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