MALAT1 suppression is a hallmark of tissue and peripheral proliferative T cells in COVID-19 Coronavirus Disease COVID MALAT1 medrxivpreprint UniOfYork UniofNewcastle NewcastleHosps
Profiling lncRNA expression in immunological cells during the response to infection could provide insights into the main transcriptional and post-transcriptional pathways functional in health and illness. Transcriptomes of tissue and peripheral T lymphocytes during the response to infections, especially COVID-19, are well-characterized. However, data on the T lymphocyte lncRNA profiles are limited and require further investigation.
About the study The researchers extended their previous analysis by examining previously published single-cell RNA sequencing datasets from bronchoalveolar lavage , post-mortem pulmonary cells, and peripheral blood samples of individuals with severe acute respiratory syndrome coronavirus 2 infections.
Results The MALAT1 lncRNA showed the greatest transcription among T lymphocytes across all datasets, with type 1 T helper lymphocytes showing the least and CD8+ resident memory lymphocytes the most significant MALAT1 expression, in CD4+ lymphocyte and CD8+ T lymphocyte populations, respectively. Significantly more transcripts showed a negative correlation with MALAT1 compared to those that showed positive correlations.
Eighty percent of genes, the expression of which significantly varied with MALAT1 expression, were the ones anti-correlating with MALAT1 expression in all T lymphocytes. The corresponding percentages were 88% and 65% for CD4+ lymphocytes and CD8+ lymphocytes in the case of correlation assessment for individual T lymphocyte populations.
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