Long-term protection unveiled: hybrid immunity guards against Omicron reinfections researchsquare immunity omicron reinfection covid COVID19 SARSCoV2
By Pooja Toshniwal PahariaJun 26 2023Reviewed by Lily Ramsey, LLM In a recent study posted to the Research Square* preprint server, researchers evaluated the impact of severe acute respiratory syndrome coronavirus 2 Wuhan-Hu-1 strain immune imprinting on antibody-based immunological responses against the antigenically distinct SARS-CoV-2 Omicron BF.7 subvariant.
Natural infection provides durable immune protection against reinfections; however, it may lead to immunological imprinting, skewing immunological responses toward the initially exposed SARS-CoV-2 antigen, depending on the antigenic distances. In addition, 13 blood samples from triple-vaccinated and WH1-infected individuals were obtained three to four months before the Omicron infection as pre-Omicron infection control group individuals.
A chemiluminescent microparticle immunoassay -based in vitro diagnostic tool was used to quantify the anti-WH1 receptor-binding domain antibodies. Hybrid immune imprinting induced higher titers against BF.7 than WIV imprinting and the naive background. Forward protection was better among hybrid-imprinted individuals than WIV vaccinees and naive individuals.
The Wuhan-Hu-1 NT/Ab ratios were reduced for imprinted individuals despite a considerable increase in Ab titers following Omicron infection, and the decrease in the NT/Ab ratio was inversely associated with the pre-infection Wuhan-Hu-1 titers.
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