The mosquito-borne infectious disease malaria resulted in about 241 million clinical episodes and 627,000 deaths in 2020.
Reviewed by Megan Craig, M.Sc.Aug 28 2023 In young children and pregnant women living in areas where the disease is endemic, a major cause of death is Plasmodium falciparum, the most virulent, prevalent, and deadly human malaria parasite.
A team led by Karine Le Roch, a professor of molecular, cell and systems biology at the University of California, Riverside, studied the role lncRNAs play in P. falciparum and found that one lncRNA -; lncRNA-ch14 -; partially regulates sexual differentiation and sex determination in P. falciparum. Karine Le Roch, professor of molecular, cell and systems biology, University of California, RiversideThe research team identified 1,768 lncRNAs in P. falciparum, of which 718 lncRNAs had never before been identified. The team validated that some of these novel lncRNAS are critical for the parasite's life cycle progression.
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