LMU medical scientists have demonstrated that important pro-inflammatory mediators are released into the bloodstream through tiny pores in the cell membrane at a very early stage of the immune response.
Many common illnesses such as arteriosclerosis and diabetes or neurodegenerative diseases such as Alzheimer's are associated with inflammatory processes. Gaining a better understanding of these processes is therefore an important stepping stone toward the development of new therapeutic approaches. Specific immune cells known as neutrophils play a decisive role in the initiation and maintenance of inflammatory processes in blood and tissue.
As the researchers report in the journal Nature Immunology, the release of these alarmins from the cell interior occurs through gasdermin D pores in the cell membrane of the neutrophils, which are formed by activation of the so-called NLRP3 inflammasome. It was already known that immune cells can form these pores after extended periods of activation.
Rapid and reversible pore formation The research team also discovered that the process is not only fast, but reversible. That is to say, the neutrophils can remove the formed pores again in a matter of minutes. This prevents the cell death that would otherwise set in, as is often observed after activation of the NLRP3 inflammasome and subsequent pore formation.
The research thus expands our knowledge of how the NLRP3 inflammasome works and opens up the possibility of therapeutically influencing inflammatory processes at a very early stage through modulation of the mechanisms involved in alarmin release.Journal reference:Pruenster, M., et al. . E-selectin-mediated rapid NLRP3 inflammasome activation regulates S100A8/S100A9 release from neutrophils via transient gasdermin D pore formation. Nature Immunology. doi.org/10.1038/s41590-023-01656-1.
Danmark Seneste Nyt, Danmark Overskrifter
Similar News:Du kan også læse nyheder, der ligner denne, som vi har indsamlet fra andre nyhedskilder.
Colorectal cancer: Aspirin found to activate protective genesLMU researchers have identified a signaling pathway by which aspirin can inhibit colorectal cancer.
Læs mere »
Researchers reveal mechanisms of alarmin release at an early stage of immune reactionMany common diseases such as arteriosclerosis and diabetes or neurodegenerative diseases such as Alzheimer's are associated with inflammatory processes. A better understanding of these processes is therefore an important building block for the development of new therapeutic options.
Læs mere »
'Metabolic elasticity': New screening strategy, possible means to curb metabolic decline in aging and obesityScientists from Duke-NUS Medical School, in collaboration with counterparts from Columbia University, have developed a new framework to measure metabolic health.
Læs mere »
Colorectal cancer: Aspirin found to activate protective genesLMU researchers have identified a signaling pathway by which aspirin can inhibit colorectal cancer.
Læs mere »
New clues to the mechanism behind treatment-resistant depressionMajor depressive disorder (MDD) is a widespread mental health condition that for many is disabling. It has long been appreciated that MDD has genetic as well as environmental influences. In a new study in Biological Psychiatry researchers identify a gene that interacted with stress to mediate aspects of treatment-resistant MDD in an animal model.
Læs mere »
Medical school on Cherokee reservation will soon send doctors to tribal, rural areasAshton Glover Gatewood decided to give medical school a second try after learning about a new campus designed for Indigenous students like herself.
Læs mere »