Courtney Lawes will skipper England on his 100th cap in Saturday's match with Fiji at Twickenham, while hooker Theo Dan makes his first start.
Jonny May starts on the wing despite not being in the World Cup squad and Alex Mitchell is named at scrum-half.
"Not only is Courtney an exceptional talent and an excellent professional, he is also a brilliant role model for young players every time he steps onto the field." Meanwhile, World Rugby successfully appealed against the decision to overturn Farrell's red card in the win over Wales on 12 August and have issued the fly-half with a four-game ban.
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