Researchers determine first crystal structure of LAG3 protein; findings could yield better cancer therapy approaches natimmunol
containing the affinity-enhancing G290E mutation and DAPI in Jurkat T cells expressing LAG3, either untreated or treated with the indicated reagents: 10 nM FGL1, 15011Fc, isotype control, 10 nM FGL1 and 300 nM 15011Fc, or 10 nM FGL1 and 300 nM isotype control.
, The number of LAG3 clusters per cell was quantified and plotted as the average per field of view with analyses of, NFAT luciferase reporter assay performed to assess the effect of FGL1 on LAG3-mediated suppression of T cell activation mediated by anti-CD3. The relative activation was obtained by normalizing baseline-subtracted luciferase signals of tested concentrations to the buffer control group.
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