Discovery suggests new way to target mantlecelllymphoma WeillCornell jclinicalinvest
Targeting lineage-defined transcriptional dependencies has emerged as an effective therapeutic strategy in cancer treatment. Through screening for molecular vulnerabilities of mantle cell lymphoma , we identified a set of transcription factors including
as a master regulator that acts upstream in the regulatory TF hierarchy. , but not its close paralog FOXO3, can reprogram myeloid leukemia cells and induce B-lineage gene expression. Finally, we demonstrate that cpd10, a small molecule identified from an enriched
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