Is vaccine status associated with the severity of Omicron SARS-CoV-2 infection in hospitalized patients? medrxivpreprint Omicron SARSCoV2 infection COVID19 coronavirus covid vaccine vaccination
By Bhavana KunkalikarOct 27 2022Reviewed by Danielle Ellis, B.Sc. In a recent study posted to the medRxiv* preprint server, researchers assessed the impact of severe acute respiratory syndrome coronavirus 2 vaccination on the occurrence and severity of symptoms in SARS-CoV-2 Omicron-infected hospitalized patients.
A retrospective, multicenter investigation was conducted across 14 hospital centers in Bulgaria, Croatia, France, and Turkey. Notwithstanding the reason for hospitalization, hospitalized patients having a polymerase chain reaction -confirmed SARS-CoV-2 diagnosis between 1 December 2021 and 3 March 2022, were included in the study. A patient was deemed fully vaccinated if that were immunized with a minimum of one Ad26.
The primary outcomes considered included oxygen supplementation, the requirement for intensive care unit admission, and 28-day mortality. In bivariate analysis, patients who were older, were male, and had comorbidities were significantly linked to one or more negative outcomes. Multivariate analysis showed that the protective effect of immunization was maintained with respect to oxygen requirement, ICU admission, and the risk of death.