Investigating the evidence of synthetic origins of SARS-CoV-2 biorxivpreprint DukeU SARSCov2 COVID19 Origins Synthetic
By Pooja Toshniwal PahariaOct 24 2022Reviewed by Aimee Molineux In a recent study posted to the bioRxiv* preprint server, researchers investigated whether severe acute respiratory syndrome coronavirus 2 originated naturally from an animal-to-human spillover or synthetically during coronavirus research experiments.
About the study In the present study, researchers investigated whether the origin of SARS-CoV-2 was natural or synthetic using a common IVGA method for ribonucleic acid virus infectious clones. Additions and removals were performed through synonymous-type mutations, creating seven fragments, of which the longest was 5721 base pair long, or covering 19% of the MERS genome. The analysis focused on SARS-CoV-2 BsaI/BsmBI sites compared to RS maps of all CoVs. Mutation analysis was performed by generating 100,000 random in silico mutants for RaTG13 and BANAl-20-52.
In the RS map analysis, the IVGA SARS-CoV-2 fingerprint showed incorporation and/or elimination of unique endonuclease enzymes ; digestion by selected enzymes resulting in five to eight fragments; the largest fragment being <eight kb; all the sticky ends were unique; all the identification sites were created via synonymous mutations; two unique identification sites could flank sites for further manipulation; identification sites could be aligned with other viral organisms for enabling...
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