Intestinal microorganisms influence white blood cell levels, study finds HokkaidoUni PNASNews
White blood cells, or granulocytes, are cells that are part of the innate immune system. The most common type of granulocyte is the neutrophil, a phagocyte that destroys microbes in the body. Low neutrophil counts in the blood is called; this condition is commonly seen in cases of leukemia or following chemotherapy. It is known that neutropenia induces granulopoiesis, the process formation of granulocytes.
A team of researchers led by Associate Professor Daigo Hashimoto and Professor Takanori Teshima at Hokkaido University's Faculty of Medicine have discovered that the gut microbiome plays a critical role in driving granulopoiesis in mice models.
The team induced prolonged neutropenia in mice models, and observed the levels of cytokines, cell signaling molecules, known to be associated with granulopoiesis. They found that two cytokines were significantly elevated: the granulocyte-colony stimulating factor and interleukin 17A . They showed that IL-17A was critical for neutrophil recovery. They confirmed that T cells are the primary source of IL-17A.
They were interested in examining if the gut microbiome influenced granulopoiesis, building on other research that suggested the gut microbiome and
Danmark Seneste Nyt, Danmark Overskrifter
Similar News:Du kan også læse nyheder, der ligner denne, som vi har indsamlet fra andre nyhedskilder.
Chris Hemsworth to take acting break after blood test health scareThor star discovered he's more likely than most to get serious health condition while filming Disney+ show - and decided to fit in quality family time
Læs mere »
Harry Styles and Olivia Wilde have 'no bad blood' after 'amicable split'Reports surfaced this week that Harry Styles and Olivia Wilde have called it a day, but the pair seem to still be on good terms.
Læs mere »
Evaluating cell-free DNA-based blood tests for early detection of multiple cancersResearchers assessed several approaches for a circulating cell-free deoxyribonucleic acid (cfDNA)-based multi-cancer early detection (MCED) test. Defining the clinical limit of detection (LOD) based on circulating tumor allele fraction (cTAF) enables the comparison of different approaches.
Læs mere »
Honey improves key measures of health, including blood sugar and cholesterol levelsHoney improves key measures of health, including blood sugar and cholesterol levels Cardiometabolic Honey Cardiology type2diabetes NutrReviews Toronto_3D_Unit
Læs mere »
First trailer for new FX series Kindred starring WeCrashed and True Blood starsThe series stars Mallori Johnson as a modern-day Black woman who is pulled back and forth through time to a 19th-century plantation.
Læs mere »
Sick Manchester teen and life-saving sister among VIPs for Black Panther showingThe Gorton teenagers are part of a campaign that encourages more people of Black heritage to donate blood
Læs mere »