Inhalation therapeutics against COVID-19 Therapeutics Coronavirus Disease COVID Inhalation Respiratory Repurposing UttaranchalUni
The COVID-19 pandemic has presented a challenge to people in terms of both treatment and prevention. Scientists were unable to provide prompt therapy or protection against severe acute respiratory syndrome coronavirus 2 infections despite advances in the medical field. A number of medications, including antivirals, were administered to patients to lower mortality and morbidity rates.
Worldwide, viruses cause numerous deaths and life-threatening diseases, but there are very few antivirals available for treatment. In contrast to bacterial infections, viral pathogens need the host protein to operate and live inside the host cells, making them challenging targets for antivirals. Ensuring that the drug does not harm the hosts while acting against viruses is the main difficulty facing antivirals.
Related StoriesThe safety of OP-DPI on lung cells was demonstrated by the MTT assay that employed Calu-3 cells originating from bronchial cancer. Due to this discovery, inhalation OP treatment was found to be more efficient and practical than oral OP treatment. However, the poor advantage of OP nebulization is confirmed by the fact that only 2% of OP prodrugs are pre-systematically transformed into the active form.
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