The role of diet in controlling the structure and function of the gut via chemical environment modulation.
By Hugo Francisco de SouzaAug 30 2023Reviewed by Lily Ramsey, LLM In a recent study published in the Nature Communications Journal, researchers explored the role of diet in controlling the structure and function of the gut via chemical environment modulation.
Their results revealed that dietary fiber could modulate gut bacterial metabolism, safeguarding against AID via a redox-driven mechanism. Research has explored the effects of probiotic supplements and oral drug adsorbers to counteract AID. Still, these approaches may increase gut disequilibrium or reduce antibiotic efficacy, prompting the need for alternative AID therapies.
Studies focusing on the role of diet on AID have found that dietary fibers, including Xanthan gum, can reduce antibiotic impacts on gut microbiome richness post-antibiotic treatment. Four-week-old C57BL/6 mice were divided into case and control cohorts. The controls were fed a modified diet utilizing glucose as the exclusive carbon source. In contrast, the cases were fed a diet devoid of glucose but rich in seven dietary fibers .
Metatranscriptomic and metagenomic sequencing of cecal contents on days one and five post-treatment was employed to broaden the gut microbiota's taxonomic and functional resolution. Metatranscriptomic sequencing was additionally used to determine alterations in metabolic functions in the gut. "These observations imply that fine modification to diet can affect microbiome recovery post-antibiotic treatment. From a translational perspective it is particularly beneficial that supplementation at the time of antibiotic administration is as effective as prior to treatment."
"In general, active metabolism is associated with increased susceptibility while metabolic dormancy confers protection. This further adds to the data displaying that glucose supplementation promotes an aerobic inflammatory GI environment."
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