First evidence drug resistant bacteria can travel from gut to lung, increasing infection risks UniofOxford NatureComms
The patient was admitted to the intensive care unit of Hospital Universitari Germans Trias i Pujol in Badalona, Spain with a primary diagnosis of seizure. This patient was recruited as part of an observational multicenter European epidemiological cohort study , which was conducted according to the principles of the Declaration of Helsinki, in accordance with the Medical Research Involving Human Subjects Act and local guidelines in the participating countries.
infection . No antibiotic use was reported in the two weeks prior to hospital admission. After 48 h of ICU admission, informed consent was obtained and the patient was enrolled in the ASPIRE-ICU study . Mechanical ventilation was started on ICU admission and was continued for a total duration of 39 days. Amoxicillin/clavulanic acid was started on ICU admission for bronchoaspiration, the suspected inhalation of oropharyngeal or gastric contents into the lower respiratory tract.
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Gut microbiota is associated with the effect of photoperiod on seasonal breeding in male Brandt’s voles (Lasiopodomys brandtii) - MicrobiomeBackground Seasonal breeding in mammals has been widely recognized to be regulated by photoperiod, but the association of gut microbiota with photoperiodic regulation of seasonal breeding has never been investigated. Results In this study, we investigated the association of gut microbiota with photoperiod-induced reproduction in male Brandt’s voles (Lasiopodomys brandtii) through a long-day and short-day photoperiod manipulation experiment and fecal microbiota transplantation (FMT) experiment. We found photoperiod significantly altered reproductive hormone and gene expression levels, and gut microbiota of voles. Specific gut microbes were significantly associated with the reproductive hormones and genes of voles during photoperiod acclimation. Transplantation of gut microbes into recipient voles induced similar changes in three hormones (melatonin, follicle-stimulating hormone, and luteinizing hormone) and three genes (hypothalamic Kiss-1, testicular Dio3, and Dio2/Dio3 ratio) to those in long-day and short-day photoperiod donor voles and altered circadian rhythm peaks of recipient voles. Conclusions Our study firstly revealed the association of gut microbiota with photoperiodic regulation of seasonal breeding through the HPG axis, melatonin, and Kisspeptin/GPR54 system. Our results may have significant implications for pest control, livestock animal breeding, and human health management. Video Abstract
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Gut microbiome, cognitive function and brain structure: a multi-omics integration analysis - Translational NeurodegenerationBackground Microbiome-gut-brain axis may be involved in the progression of age-related cognitive impairment and relevant brain structure changes, but evidence from large human cohorts is lacking. This study was aimed to investigate the associations of gut microbiome with cognitive impairment and brain structure based on multi-omics from three independent populations. Methods We included 1430 participants from the Guangzhou Nutrition and Health Study (GNHS) with both gut microbiome and cognitive assessment data available as a discovery cohort, of whom 272 individuals provided fecal samples twice before cognitive assessment. We selected 208 individuals with baseline microbiome data for brain magnetic resonance imaging during the follow-up visit. Fecal 16S rRNA and shotgun metagenomic sequencing, targeted serum metabolomics, and cytokine measurements were performed in the GNHS. The validation analyses were conducted in an Alzheimer’s disease case–control study (replication study 1, n = 90) and another community-based cohort (replication study 2, n = 1300) with cross-sectional dataset. Results We found protective associations of specific gut microbial genera (Odoribacter, Butyricimonas, and Bacteroides) with cognitive impairment in both the discovery cohort and the replication study 1. Result of Bacteroides was further validated in the replication study 2. Odoribacter was positively associated with hippocampal volume (β, 0.16; 95% CI 0.06–0.26, P = 0.002), which might be mediated by acetic acids. Increased intra-individual alterations in gut microbial composition were found in participants with cognitive impairment. We also identified several serum metabolites and inflammation-associated metagenomic species and pathways linked to impaired cognition. Conclusions Our findings reveal that specific gut microbial features are closely associated with cognitive impairment and decreased hippocampal volume, which may play an important role in dementia development.
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Single-cell profiling of vascular endothelial cells reveals progressive organ-specific vulnerabilities during obesity - Nature MetabolismBondareva and Rodríguez-Aguilera et al. use scRNA-seq to analyze transcriptomes of 375,000 endothelial cells from seven organs in male mice at various stages of obesity to identify organ-specific vulnerabilities.
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Multi-omics signatures of the human early life exposome - Nature CommunicationsEnvironmental exposures in early life can have lasting health effects, but the molecular mechanisms are not well understood. Here, the authors discover |1000 associations between exposure factors and child multi-omics profiles, revealing signatures for diet, toxic chemical compounds, essential trace elements, and weather conditions.
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Beetroot juice appears to affect gut microbiome, positively impacting intestinal and systemic healthBeetroot juice appears to affect gut microbiome, positively impacting intestinal and systemic health Microbiome Gut Blood Dysbiosis Food Genomic Polyphenol Beetroot Beet UniversityLeeds ELSfoodscience
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A developmental atlas of somatosensory diversification and maturation in the dorsal root ganglia by single-cell mass cytometry - Nature NeuroscienceSomatosensory neurons detect pain, temperature and touch. Keeler et al. constructed a single-cell, protein-level atlas of nearly 3 million cells from the mouse dorsal root ganglia, covering 13 days of embryonic and postnatal development.
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