Gut health breakthrough: probiotics show promise in managing PCOS in obese adolescents Nutrients_MDPI unipv PCOS polycysticovaries obesity probiotic probiotics adolescents
By Vijay Kumar MalesuJul 18 2023Reviewed by Lily Ramsey, LLM A recent review published in the Nutrients Journal examines the impact of probiotic/symbiotic supplementation in adolescents with obesity and polycystic ovary syndrome , exploring their potential benefits on hormonal, metabolic, and inflammatory profiles.
Recent research has shed light on the role of gut dysbiosis in the pathogenesis of PCOS. Dysbiosis, an imbalance in the gut microbiota composition, has been observed in both human and animal models with PCOS. The intersection of polycystic ovary syndrome and obesity: implications and approaches PCOS involves a self-sustaining hormonal imbalance, with an increased luteinizing hormone: follicle-stimulating hormone ratio and elevated testosterone levels due to reduced sex hormone-binding globulin , impacting the ovaries and leading to hyperandrogenism.
Related StoriesObesity-induced insulin resistance and hyperinsulinemia contribute to PCOS pathogenesis, with IR prevalence ranging from 44% to 70% in PCOS patients. IR exacerbates metabolic and reproductive abnormalities, and insulin receptors in ovarian cells influence follicular development and steroidogenesis.
While no particular bacterium has been recognized as the causal factor, some studies suggest increased levels of pro-inflammatory bacteria like Prevotella and Escherichia coli in PCOS patients. Specific changes include reduced beneficial bacteria like Lactobacilli and Bifidobacteria and increased pathogenic bacteria like Escherichia and Shigella. Such alterations affect the synthesis of short-chain fatty acids, impacting metabolism, immunity, and gut barrier integrity.
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