Griffith University researchers are on the brink of a technological breakthrough in vaccine development with a possible new vaccine modality.
Professor Bernd Rehm and Dr Shuxiong Chen from the Griffith Institute for Drug Discovery and Griffith's Centre for Cell Factories and Biopolymers have succeeded in developing a new vaccine modality that is a stable particulate vaccine.To demonstrate this vaccine approach, it was tested with a more established Griffith vaccine against Strep A that is currently performing strongly in human clinical trials in Canada.
To develop the vaccine, we reprogrammed bacterial cell factories to assemble biopolymer particles coated with the Griffith Strep A antigens and found the particles were safe and protected against infection. Related StoriesGroup A Streptococcus is a global human pathogen that leads to a wide range of infections from illnesses such as mild pharyngitis and impetigo to invasive diseases such as toxic shock syndrome, necrotising fasciitis, and cellulitis.
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