Frequent zoonotic spillover of diverse sarbecoviruses in communities interacting with wildlife Zoonosis Coronavirus Disease COVID Sarbecoviruses InfectiousDiseases Pandemic SARSCoV2 ISID_org ucdavis dukenus
By Dr. Priyom Bose, Ph.D.Mar 6 2023Reviewed by Danielle Ellis, B.Sc. Sarbecoviruses, such as severe acute respiratory syndrome coronavirus 2 , are a subgenus of Coronaviridae that predominantly infect bats. Research has shown that such viruses also have the potential to infect humans. Sarbecoviruses are most likely to emerge in populations in Southeast Asia, which have not been adequately surveyed to date.
Research into the correlations between sarbecovirus infections in humans and activities that bring them in close contact with bats is scarce. Studies should characterize the currently unrecognized sarbecoviruses that are circulating and evaluate their potential to spillover over to people. To evaluate associations between animal contact risk and human demographic factors, all covariates were first evaluated to rule out potential confounding. To determine associations between high-risk human-animal contact behaviors and seropositivity for sarbecoviruses, Pearsons ��2 tests were used.
The seropositivity rate was observed to be high in people engaged in extractive industries, particularly logging. Humans are brought closer to wildlife in this profession through bushmeat hunting and proximity to the forest, and as a result, the risk of zoonotic transmission rises. This highlights the importance of vigilance and access to infectious disease diagnostics in these communities. Similar results have been documented in other studies conducted in Myanmar and globally.
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