'We need to think big in antibiotics research,' says Cesar de la Fuente. 'Over one million people die every year from drug-resistant infections, and this is predicted to reach 10 million by 2050. There hasn't been a truly new class of antibiotics in decades, and there are so few of us tackling this issue that we need to be thinking about more than just new drugs. We need new frameworks.'
Marrying artificial intelligence with advanced experimental methods, the Machine Biology Group has mined the ancient past for future medical breakthroughs, bringing extinct molecules back to life. Credit: Ella Marushchenko
De la Fuente's lab, the Machine Biology Group, creates these new frameworks using potent partnerships in engineering and thewith advanced experimental methods, the group has mined the ancient past for future medical breakthroughs. In a recent study published ingenetic material —and found dozens of small protein sequences with antibiotic qualities. Their lab then worked to synthesize these molecules, bringing these long-since-vanished chemistries back to life.," says de la Fuente."These are the building blocks of a peptide, a small protein. Then we can make these molecules using a method called 'solid-phase chemical synthesis.' We translate the recipe of amino acids into an actual molecule and then build it.
In fact, the group's previous research had already shown that some of the antimicrobial molecules they found were hidden away, encrypted within proteins associated with completely different systems and functions in the body.
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