Flavonoids with potential to fight allergies and inflammation Inflammation Allergen Allergy AntiInflammatory Antioxidant Quercetin Kaemferol Myricetin Luteolin SGGW_Warszawa UniversiteLiege univ_lille
Chronic inflammation is crucial to the initiation and progression of chronic disorders such as diabetes, cancer, hypertension, asthma, and allergies. Bioactive flavonoids are plentiful in numerous food groups, including vegetables, nuts, fruits, drinks, and cereals. Recent research on flavonoids has revealed their capacity to regulate or prevent inflammation.
Flavonoids as effective anti-inflammatory agents Flavonoids function as anti-inflammatory agents by blocking the transcription factors as well as regulatory enzymes responsible for inflammation and its propagation, among other mechanisms.
in vitro and in vivo studies of flavonoids Luteolin, myricetin, kaempferol, and quercetin were found to be beneficial against allergy-specific cytokines in in vitro and in vivo experiments. All have been reported to inhibit the generation of interleukin -4 and IL-13 from mast cells and basophils. Kaemferol Kaemferol is a plant-based flavonol with anti-allergic, anti-inflammatory, and antioxidant activities demonstrated in animal and human studies. By interfering with NF-κB signaling, it significantly controls allergic airway inflammation among mice. Kaempferol decreased the CD69 expression and the generation of allergen-inducing inflammatory cytokines, such as IL-12.
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