A study published in Cancer Cell International discusses the crucial role of pyroptosis-related risk scores in colorectal cancer, thus providing a novel and efficient perspective for tumor prognosis and treatment prediction.
]. After merging, a total of 57 pyroptosis-related genes were retained for subsequent analysis in this study. For reducing the batch effect, the RNA expression data from the GEO cohort and the TCGA cohort were processed by “sva” R package. In this study, CRC samples with intact information of OS were included for further analysis. And samples whose OS time was 0 were excluded.
The median PRS was used as the cut-off value, all samples were divided into high- and low-risk score groups. Principal component analysis was performed by “limma” R package to verify whether the risk model could distinguish high- and low-risk score groups. We compared prognosis of CRC samples between high- and low-risk score groups using the Kaplan–Meier method via the “survival” R package.
: Table S1. Beyond that, we obtained the status data of the CpG island methylator phenotype , chromosomal instability , DNA mismatch repair , and
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