New research has found the most common form of breast cancer presents differing metabolic signatures in the blood of African American women with estrogen receptor-positive breast cancer compared with non-Hispanic white women. The scientists also identified a protein—negative elongation factor complex E—that was linked with higher mortality rates among African American women with estrogen receptor-positive breast cancer.
, may help explain some of the molecular processes driving higher rates of the disease—especially more aggressive forms of it—in African American. ER-positive breast cancer accounts for about 70%-80% of all breast cancer cases, and African American women are 40% more likely to die from it than white women, said Zeynep Madak-Erdogan, a professor of nutritional sciences and of food science and human nutrition at the University of Illinois Urbana-Champaign and co-author of the paper.
"Although the tumors are often caught at earlier stages, patients from lower-income neighborhoods such as Chicago's South Side are more likely to have poor outcomes. That suggests there are some biological factors driving these differing effects," she said. The team analyzed 83 metabolites in the women's blood and found that African American women with ER-positive breast cancer had decreased circulating levels of amino acids—including the antioxidant methionine—compared with women in the healthy control group.
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