Environmental toxicants contribute to obesity and metabolic disease MetabolicDisease Obesity Environmental toxicants Pharmacology McMasterU MacMODR HZAU_China
Obesity results from higher energy intake compared to energy expenditure, which in turn results in an increase in adiposity. The calorie gap for preventing weight gain in various populations is only 8.2 to 61.2 kcal/day. A sedentary lifestyle and excessive energy consumption may not entirely account for the increasing prevalence of global obesity and accompanying metabolic diseases, despite the robustness with which energy balance is regulated.
Thermogenic activities performed by active BAT per gram of tissue oxidize plasma triglycerides and glucose at a relatively high rate. However, it should be noted that during exposure to cold, skeletal muscle-based thermogenesis contributes significantly more to energy expenditure because of its large bulk. Four weeks of acclimation to cold is sufficient for adults to increase BAT thermogenesis and decrease skeletal muscle shivering.
Following treatment with 1 pM CPF, BAT cells were subjected to unbiased RNA sequencing, which revealed that the low dose of CPF caused noticeable alterations in mitochondrial gene expression. Subsequent research revealed that these changes were linked to deficits in mitochondrial respiration.
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