Scientists identify how repeated cocaine use increases addictiveness
Experimental designs of the induction and expression phase of cocaine-induced hyperlocomotion with a timeline. Groups were distributed according to the experiment. Represents that the first and second injection during the sensitization period was administered concerning the group treatment. Both injections were applied on the same day. During the sensitization period, the injections were applied on the odd days .
The one-way ANOVA test was performed, followed by the Duncan post hoc test.Locomotor activity of the animals in the expression phase during the habituation period, the first day of cocaine, the last day of cocaine, administered in a paired way or not to the environmental context, followed by the cocaine challenge after a not-handled 10-day period.
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