Did COVID-19 mortality differ between patients with cancer and the general US population depending on which SARS-CoV-2 variant was dominant?

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Did COVID-19 mortality differ between patients with cancer and the general US population depending on which SARS-CoV-2 variant was dominant?
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Researchers comparatively evaluated COVID-19 mortality among cancer patients during different periods of the SARS-CoV-2 outbreak.

By Pooja Toshniwal PahariaSep 4 2023Reviewed by Sophia Coveney In a recent study published in JAMA Oncology, researchers comparatively evaluated coronavirus disease 2019 -related mortality among cancer patients and the general public of the United States during different periods of the severe acute respiratory syndrome coronavirus 2 outbreak.

Investigating COVID-19-associated mortality rates in different periods of the COVID-19 pandemic, characterized by the predominance of different SARS-CoV-2 variants of concern , varied vaccination rates, and changes in COVID-19 prevention measures, may provide insight into future COVID-19-associated mortality risk among cancer patients.

Data were obtained from the Centers for Disease Control and Prevention's Wide-Range Online Data for Epidemiologic Research database. To investigate COVID-19 mortality among cancer patients, the researchers chose people who had both cancer and COVID-19 as reasons for death. Death certificates were retrieved to obtain race information and assess the demographic features of the sample population during the Wuhan-Hu-1, Delta, and Omicron periods. Age and cancer location were used to conduct subgroup analysis.

On the contrary, in the general population of the US, most deaths from COVID-19 were reported during Wuhan-Hu-1 predominance , with 21% lower COVID-19-associated deaths during the Omicron wave between December 2021 and February 2022 compared to the Wuhan-Hu-1 peak period.

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