A one-two punch: Low levels of a flavoring chemical and mild flu may damage lungs
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Armigeres subalbatus, a potential vector for Zika virus - BugBittenProf. Xiaoguang Chen and his team from Southern Medical University, China investigated the infection and transmission of Armigeres subalbatus to Zika virus and dengue virus. They found that Zika virus but not dengue virus (serotype 2) can infect Ar. subalbatus via blood meal and artificial urine, and the infected mosquitoes can transmit Zika virus to suckling mice by bite. This study was recently published in Infectious Diseases of Poverty.
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Distinct translatome changes in specific neural populations precede electroencephalographic changes in prion-infected miceAuthor summary Prions are infectious agents composed of a misfolded protein. When isolated from a mammalian brain and transferred to the same host species, prions will cause the same neurodegenerative disease affecting the same brain regions and cell types. This concept of selective vulnerability is also a feature of more common types of neurodegenerative diseases, such as Alzheimer’s, Parkinson’s, and Huntington’s. To better understand the mechanisms behind selective vulnerability, we studied disease responses of five cell types with different vulnerabilities in prion-infected mice at two different disease stages. Responses were measured as changes to mRNAs undergoing translation, referred to as the translatome. Before prion-infected mice demonstrated typical disease signs, electroencephalography (a method used clinically to characterize neurodegeneration in humans) revealed brain changes resembling those in human prion diseases, and surprisingly, the translatomes of all cells were drastically changed. Furthermore, before electroencephalography changes emerged, three cell types made unique responses while the most vulnerable cell type did not. These results suggests that mechanisms causing selective vulnerability will be difficult to dissect and that therapies will likely need to be provided before clinical signs emerge and individually engage multiple cell types and their distinct molecular pathways.
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Harry Kane to read Bedtime Story on CBeebies tonightThe Three Lions skipper is set to read a book that follows a shy little mouse who sets out on a journey to find his roar
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Crimea bridge: Russia ramps up security after blastMoscow moves to secure the key connector and repair it as soon as possible after the explosion.
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