The relationships between hormone replacement therapy (HRT), serum cholesterol levels, and dementia incidence.
By Pooja Toshniwal PahariaOct 25 2023Reviewed by Lily Ramsey, LLM In a recent study published in Nutrition, researchers determined the relationships between hormone replacement therapy , serum cholesterol levels, and dementia incidence among post-menopausal women in Taiwan.
Low cholesterol levels may be linked to cell membrane development and maintenance of membranes, including cranial membranes. Elevated serum cholesterol might result in atherosclerosis and narrow blood vessels, impairing cognitive function. The participants were followed longitudinally to assess dementia conversion. Cox regression modeling was performed to investigate the effects of statistical quartiles of low-density lipoprotein-cholesterol and total cholesterol levels on dementia conversion, adjusting for gender, age, comorbidities, educational attainment, neuropsychological symptoms, neuropsychiatric evaluations, HRT, medications, systolic blood pressure, fasting blood glucose, and creatinine levels.
Dementia diagnosis was based on the National Institute on Aging-Alzheimer’s Association criteria, global CDR scores of 0.5 and higher, and CDR scale sum of boxes scores of 4.5 and higher.
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