Cryo-electron tomography helps visualize platelet deformation due to SARS-CoV-2 spike protein biorxivpreprint NIH Platelet SARSCoV2 COVID19 SpikeProtein Spike CryoelectronTomography
By Neha MathurNov 28 2022Reviewed by Aimee Molineux In a recent study posted to the bioRxiv* server, researchers used cellular cryo-electron tomography to demonstrate the role of severe acute respiratory syndrome coronavirus 2 spike protein in coronavirus disease 2019 -triggered severe coagulopathies.
Many theories have reasoned the causes of these abnormalities. Yet, it is unclear whether SARS-CoV-2 directly interacts with platelets, or cytokines, antiphospholipid antibodies, and other immune cells mediate SARS-CoV-2 effects. Study findings Discoid-shaped platelets were predominant in the absence of S protein; however, deformed platelets appeared elongated in their presence. Besides extensive elongation, the researchers also noted an increased spreading of platelets in the presence of S protein. They found a population of abnormally shaped platelets resembling a proplatelet-like appearance, indicating an impact on the cytoskeleton-dependent platelet maturation process.
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